Atorvastatin hemicalcium salt
作者：齊岳
發(fā)布時(shí)間：2023-09-07
09:28:11
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Atorvastatin hemicalcium salt
產(chǎn)品描述：
| 產(chǎn)品描述 | Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. |
| 靶點(diǎn)活性 | HMG-CoA reductase:8 nM |
| 體外活性 | 在statin處理過的大鼠中,Atorvastatin降低p22phox和NOX1血管mRNA的表達(dá),同時(shí)提高主動(dòng)脈過氧化氫酶的表達(dá).在膽固醇喂養(yǎng)的兔子中,Atorvastatin抑制C反應(yīng)蛋白的血清水平的增加. |
| 體內(nèi)活性 | 在血管平滑肌細(xì)胞中, Atorvastatin（0.1 μM）能夠抑制血管緊張素Ⅱ和壞死因子-α誘導(dǎo)的NF-κB活化；Atorvastatin（1 μM）減少血管緊張素Ⅱ和壞死因子-α誘導(dǎo)的IP-10的表達(dá)。 |
| 細(xì)胞實(shí)驗(yàn) | Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104?cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients. |
| 別名 | CI-981, Atorvastatin Calcium, 阿托伐他汀鈣, Lipitor, Atorvastatin hemicalcium, Sortis |
| 分子量 | 1155.34 |
| 分子式 | 2(C33H34FN2O5)·Ca |
| CAS No. | 134523-03-8 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 57.8 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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