Alogliptin Benzoate
作者：齊岳
發(fā)布時(shí)間：2023-09-07
09:28:11
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Alogliptin Benzoate
產(chǎn)品描述：
| 產(chǎn)品描述 | Alogliptin Benzoate(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines. |
| 靶點(diǎn)活性 | DPP-4:<10 nM |
| 體外活性 | Alogliptin(SYR-322) is a potent inhibitor of DPP-4 and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. Alogliptin is not an inhibitor of CYP-450 enzymes and does not block the hERG channel at concentrations up to 30 μM. [1] |
| 體內(nèi)活性 | Alogliptin(SYR-322) produces dose-dependent improvements in glucose tolerance and increases plasma insulin levels in female Wistar fatty rats. [1] Acute administration of alogliptin results in a significant decrease in plasma DPP-4 activity, and increases plasma active GLP-1. Alogliptin improves glucose tolerance at a dose of 0.3 mg/kg and higher, with a dose-dependent increase in plasma IRI, suggesting that improved glucose tolerance results from the ability of alogliptin to enhance insulin secretion. [2] |
| 別名 | 苯甲酸阿格列汀, SYR 322, Alogliptin(SYR-322)benzoate |
| 分子量 | 461.51 |
| 分子式 | C25H27N5O4 |
| CAS No. | 850649-62-6 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 63 mg/mL (136.5 mM)
Ethanol: <1 mg/mL
H2O: 2 mg/mL (4.33 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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