Naproxen sodium
作者：齊岳
發(fā)布時間：2023-09-08
09:05:27
點擊數(shù)：
產(chǎn)品名稱：Naproxen sodium
產(chǎn)品描述：
| 產(chǎn)品描述 | Naproxen is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties. |
| 靶點活性 | COX-1:8.7 μM, COX-2:5.2 μM |
| 體外活性 | 在Carrageenan誘導關節(jié)炎的痛覺缺失大鼠模型中（IC50=27 μM）和酵母性發(fā)熱大鼠模型中（IC50=40 μM）, Naproxen能夠產(chǎn)生抑制作用.在大鼠中,Naproxen能夠抑制脂多糖誘導的PGE2（IC50=12.8 μM）和TXB2（IC50=5.9 μM）的產(chǎn)生. |
| 體內(nèi)活性 | 在HCA-7結腸*細胞中（IC50=1.45 mM）,高濃度的Naproxen能夠誘導細胞凋亡。在細胞內(nèi),Naproxen能夠抑制COX-1（IC50=2.2 μg/mL）和 COX-2（IC50=1.3 μg/mL）。 |
| 激酶實驗 | COX-1 and COX-2 activities in intact cells: For the determination of COX-1 and COX-2 inhibition, bovine aortic endothelial cells (BAEC) are incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), and cultured J774.2 macrophages are treated with endotoxin at 1 μg/mL for 12 hours to induce COX-2 followed by incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), respectively. Arachidonic acid (30 μM) is then added, and the cells are incubated for a further 15 minutes at 37 °C. The medium is then removed, and radioimmunoassay is used to measure the formation of 6-keto-PGF1α, PGE2, thromboxane B2, or PGF2α for the assessment of IC50 for COX-1 and COX-2. |
| 細胞實驗 | Cells are exposed to Naproxen for 24 and 48 hours, respectively. At the end of incubation, cells are harvested by trypsinization, stained with trypan blue solution (0.04% wt/vol) and counted in a Neubauer haemocytometer chamber for the determination of cell viability.(Only for Reference) |
| 別名 | Miranax, Naprelan, Anaprox, RS-3650, 萘普生鈉 |
| 分子量 | 252.24 |
| 分子式 | C14H13NaO3 |
| CAS No. | 26159-34-2 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 11.9 mM
H2O: 198.2 mM
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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