Hydroxychloroquine sulfate
作者：齊岳
發(fā)布時間：2023-09-08
09:03:31
點擊數(shù)：
產(chǎn)品名稱：Hydroxychloroquine sulfate
產(chǎn)品描述：
| 產(chǎn)品描述 | Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. |
| 體外活性 | Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis[2]. |
| 體內(nèi)活性 | The treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent[3]. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals[4]. |
| 激酶實驗 | In vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot. |
| 細(xì)胞實驗 | All cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference) |
| 別名 | 羥基氯喹, Acidum iopanoicum, 羥氯喹, HCQ sulfate |
| 分子量 | 433.95 |
| 分子式 | C18H26ClN3O·H2SO4 |
| CAS No. | 747-36-4 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: Insoluble
H2O: 10 mM
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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