L-BUTHIONINE-(S,R)-SULFOXIMINE
作者：齊岳
發(fā)布時間：2023-09-07
09:28:15
點(diǎn)擊數(shù)：
產(chǎn)品名稱：L-BUTHIONINE-(S,R)-SULFOXIMINE
產(chǎn)品描述：
| 產(chǎn)品描述 | L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH. |
| 靶點(diǎn)活性 | melanoma:1.9 μM, breast:8.6 μM, ovarian tμMor:29 μM |
| 體外活性 | IC50 values (microM) for L-buthionine-S,R-sulfoximine (BSO) on melanoma, breast and ovarian tumor specimens were 1.9, 8.6, and 29, respectively. The IC90 for melanoma was 25.5 microM, a level 20-fold lower than steady-state levels achieved clinically [1]. GSH loss induced by L-buthionine-S,R-sulfoximine (BSO) leads to overproduction of reactive oxygen species (ROS) and triggers apoptosis of MYCN-amplified neuroblastoma cells [2]. |
| 體內(nèi)活性 | Systemic BSO administration selectively altered GSH homeostasis and EAAT3 levels in the mice cerebellum. Intraperitoneal treatment of mice with 6?mmol/kg of BSO depleted GSH and GSSG in the liver at 2?h of treatment [3]. |
| 別名 | L-Butionine sulfoximine, 丁硫氨酸-亞砜亞胺 |
| 分子量 | 222.31 |
| 分子式 | C8H18N2O3S |
| CAS No. | 83730-53-4 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: Insoluble
H2O: 10 mM
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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