BMS-202
作者：齊岳
發(fā)布時(shí)間：2023-09-13
16:37:17
點(diǎn)擊數(shù)：
產(chǎn)品名稱：BMS-202
產(chǎn)品描述：
| 產(chǎn)品描述 | PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1. |
| 靶點(diǎn)活性 | PD-1/PD-L1 interaction:0.018 μM |
| 體外活性 | BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1]. |
| 激酶實(shí)驗(yàn) | All binding studies are performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (with v) bovine serum albumin and 0.05% (v/v) Tween-20. For the PD-l-Ig/PD-Ll-His binding assay, inhibitors are pre-incubated with PD-Ll-His (10 nM final) for 15 m in 4 μL of assay buffer, followed by addition of PD-l-Ig (20 nM final) in 1 μL of assay buffer and further incubation for 15 m. PD-L1 from either human, cyno, or mouse are used. HTRF detection is achieved using europium crypate-labeled anti- Ig (1 nM final) and allophycocyanin (APC) labeled anti-His (20 nM final). Antibodies are diluted in HTRF detection buffer and 5 μL is dispensed on top of binding reaction. The reaction mixture is allowed to equilibrate for 30 minutes and signal (665 nm/620 nm ratio) is obtained using an En Vision fluorometer. Additional binding assays are established between PD-1-Ig/PD-L2-His (20, 5 nM, respectively), CD80-His/PD-Ll-Ig (100, 10 nM, respectively) and CD80-His/CTLA4-Ig (10, 5 nM, respectively). |
| 別名 | PD1-PDL1 inhibitor 2, PD-1/PD-L1 inhibitor 2 |
| 分子量 | 419.52 |
| 分子式 | C25H29N3O3 |
| CAS No. | 1675203-84-5 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 76 mg/mL(181.2 mM)
Ethanol: 83 mg/mL (197.85 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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