Valproic Acid
作者：齊岳
發(fā)布時間：2023-09-13
09:11:15
點擊數(shù)：
產(chǎn)品名稱：Valproic Acid
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 其他（植物來源） > 其他 |
| 產(chǎn)品描述 | Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase. |
| 靶點活性 | HDAC1:0.4 mM |
| 體內(nèi)活性 | Xylazine can be used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine-induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence) [2]. |
| 別名 | 2-Propylpentanoic Acid, 2-Propylvaleric Acid, Depakine, Sodium valproate, VPA, 丙戊酸 |
| 分子量 | 144.21 |
| 分子式 | C8H16O2 |
| CAS No. | 99-66-1 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 100 mg/mL (693.43 mM),Need ultrasonic
H2O: 1 mg/mL (6.93 mM),Need ultrasonic and warming
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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