5-Aminolevulinic acid hydrochloride
作者：齊岳
發(fā)布時(shí)間：2023-09-12
09:13:41
點(diǎn)擊數(shù)：
產(chǎn)品名稱(chēng)：5-Aminolevulinic acid hydrochloride
產(chǎn)品描述：
| 植物來(lái)源 | 天然產(chǎn)物 > 其他（植物來(lái)源） > 其他 |
| 產(chǎn)品描述 | Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. | ||||||||||||||||
| 體外活性 | 5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumors. Median follow-up was 35.4 months (95% CI 1.0-56.7). A contrast-enhancing tumor was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (the difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression-free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2].
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| 別名 | 5-Aminolevulinic acid HCl, 氨基酮戊酸, Hydrangin, ALA hydrochloride, 5-ALA, 5-氨基乙酰丙酸鹽 |
| 分子量 | 167.59 |
| 分子式 | C5H10ClNO3 |
| CAS No. | 5451-09-2 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 31 mg/mL (185 mM)
Ethanol: 6 mg/mL (35.8 mM)
DMSO: 32 mg/mL (190.9 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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