Motixafortide TFA(664334-36-5,Free)
作者：齊岳
發(fā)布時間：2023-09-12
09:12:42
點擊數(shù)：
產(chǎn)品名稱：Motixafortide TFA(664334-36-5,Free)
產(chǎn)品描述：
| 產(chǎn)品描述 | Motixafortide is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression. |
| 靶點活性 | CXCR4:～1 nM |
| 體外活性 | Treatment with BL-8040 induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to BL-8040 undergoes differentiation. BL-8040 induces the apoptosis of AML cells in vitro, which is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. BL-8040-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways. |
| 體內(nèi)活性 | BL-8040 also synergizes with FLT3 inhibitors to induce AML cell death. Importantly, this combined treatment prolongs the survival of tumor-bearing mice and reduces minimal residual disease in vivo. |
| 別名 | TF 14016 TFA, BKT140 TFA, T140 TFA, BL-8040 TFA |
| 分子量 | 2273.54 |
| 分子式 | C99H145F4N33O21S2 |
| CAS No. | T14665L |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 100 mg/mL (46.31 mM),need ultrasonic
DMSO: 100 mg/mL (46.31 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齊岳生物科技有限公司是集化學(xué)科研和定制與一體的高科技化學(xué)公司。業(yè)務(wù)范圍包括化學(xué)試劑和產(chǎn)品的研發(fā)、生產(chǎn)、銷售等。涉及產(chǎn)品為通用試劑的分銷、非通用試劑的定制與研發(fā)，涵蓋生物科技、化學(xué)品、中間體和化工材料等領(lǐng)域。
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