TC14012 acetate
作者：齊岳
發(fā)布時(shí)間：2023-09-12
09:09:28
點(diǎn)擊數(shù)：
產(chǎn)品名稱：TC14012 acetate
產(chǎn)品描述：
| 產(chǎn)品描述 | TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity. |
| 靶點(diǎn)活性 | CXCR7:350 nM (EC50), CXCR4:19.3 nM |
| 體外活性 | TC14012 (1 mM) inhibits more than 95% the infection of the CXCR4-expressing cells by the HXB2 (X4) or 89.6 (dual-tropic) strain. TC14012 (1 mM) does not inhibit all the infection of the CCR5-expressing cells by the SF162 (R5) or 89.6 (dualtropic) strain. TC14012 leads to erk 1/2 phosphorylation in U373 cells, which express endogenous CXCR7 but not CXCR4. CXCR7 and the CXCR7-Cter4 chimera are able to recruit arrestin upon stimulation with TC14012 whereas CXCR4 and CXCR4-Cter7 remain silent. |
| 別名 | TC14012 acetate(368874-34-4 free base) |
| 分子量 | 2126.47 |
| 分子式 | C92H144N34O21S2 |
| CAS No. | TP2112L |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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