AICAR phosphate
作者：齊岳
發(fā)布時間：2023-09-12
09:06:05
點擊數(shù)：
產(chǎn)品名稱：AICAR phosphate
產(chǎn)品描述：
| 產(chǎn)品描述 | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinflammatory cytokines and iNOS production[1][2]. |
| 體外活性 | The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively[1]. HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. |
| 體內(nèi)活性 | Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt-1*day-1 or saline control (C) for 14 days. All mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis, at 24 h after the last injection (including a 12-h fast). Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change[3]. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups[4]. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. |
| 別名 | Acadesine phosphate, AICA Riboside phosphate |
| 分子量 | 356.23 |
| 分子式 | C9H17N4O9P |
| CAS No. | 681006-28-0 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 75 mg/mL (210.54 mM)
H2O: 180 mg/mL (505.29 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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