XRK3F2
作者：齊岳
發(fā)布時間：2023-09-12
08:55:08
點擊數(shù)：
產(chǎn)品名稱：XRK3F2
產(chǎn)品描述：
| 產(chǎn)品描述 | XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. |
| 體外活性 | XRK3F2 inhibits p62-ZZ domain signaling and rescues Myeloma-induced Gfi1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression. XRK3F2 prevents MM-induced upregulation of Gfi1 and repression of the Runx2 gene when present in MM-preOB co-cultures. p62-ZZ-domain blocking by XRK3F2 prevents MM conditioned media and TNF plus IL7-mediated Gfi1 mRNA upregulation and the concomitant Runx2 repression. XRK3F2 decreased MM-induced GFI1 occupancy at the Runx2-P1 promoter and prevented recruitment of HDAC1, thus preserving the transcriptionally permissive chromatin mark H3K9ac on Runx2 and allowing osteogenic differentiation[1]. |
| 分子量 | 435.89 |
| 分子式 | C23H24ClF2NO3 |
| CAS No. | 2375193-43-2 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 135.0 mg/mL (309.7 mM),Need ultrasonic
H2O: 0.8 mg/mL (1.9 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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