Tenovin-6
作者：齊岳
發(fā)布時間：2023-09-11
09:29:21
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Tenovin-6
產(chǎn)品描述：
| 產(chǎn)品描述 | Tenovin-6 is a p53 transcriptional activity agonist. |
| 靶點(diǎn)活性 | SIRT3:67 μM, SIRT1:21 μM, SIRT2:10 μM |
| 體內(nèi)活性 | Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1]. |
| 激酶實(shí)驗(yàn) | Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr. |
| 細(xì)胞實(shí)驗(yàn) | The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve. |
| 別名 | Tenovin 6 |
| 分子量 | 454.63 |
| 分子式 | C25H34N4O2S |
| CAS No. | 1011557-82-6 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 91 mg/mL (200.2 mM)
H2O: 90 mg/mL (198 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齊岳生物科技有限公司是集化學(xué)科研和定制與一體的高科技化學(xué)公司。業(yè)務(wù)范圍包括化學(xué)試劑和產(chǎn)品的研發(fā)、生產(chǎn)、銷售等。涉及產(chǎn)品為通用試劑的分銷、非通用試劑的定制與研發(fā)，涵蓋生物科技、化學(xué)品、中間體和化工材料等領(lǐng)域。
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