PHY34
作者：齊岳
發(fā)布時(shí)間：2023-09-11
09:27:39
點(diǎn)擊數(shù)：
產(chǎn)品名稱：PHY34
產(chǎn)品描述：
| 產(chǎn)品描述 | PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo. |
| 體外活性 | In HGSOC cell lines, PHY34 showed cytotoxicity with IC50 of 4 nM. Its IC50 values in MDA-MB-435 and MDAMB-231 cell lines were 23 nM and 5.2 nM, respectively. In OVCAR3 cells, 100 nM PHY34 increased the level of early and late apoptotic cells [1]. |
| 體內(nèi)活性 | In the hollow fiber deflector, PHY34 significantly inhibited the growth of cancer cells; In the transplanted tumor model, PHY34 reduced the ovarian tumor load. The bioavailability of mice was 56.6% after intravenous injection of 0.6 mg/kg, intraperitoneal injection of 1.8 mg/kg or oral administration of 75 mg/kg PHY34, and 2.5% after oral administration. After oral administration, the systemic clearance (CL) was 194.1 L/hr/kg, which was nearly 40 times the liver blood flow of mice, indicating that PHY34 had significant extrahepatic clearance. After oral administration, PHY34 was rapidly absorbed, and Tmax was 0.25 hr [1]. |
| 分子量 | 582.55 |
| 分子式 | C30H30O12 |
| CAS No. | 2130033-55-3 |
存儲(chǔ)
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMF: 30 mg/mL
DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
DMSO: 90mg/mL (154.5mM)
Ethanol: 10 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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