Hemin
作者：齊岳
發(fā)布時間：2023-09-11
09:05:11
點擊數(shù)：
產(chǎn)品名稱：Hemin
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 其他（植物來源） > 其他 |
| 產(chǎn)品描述 | Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer. |
| 體外活性 | Hemin treatment decreased cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, we observed enhancement of anti-proliferative effects of statins by hemin, documented as decreased cell proliferation after 48 h of co-treatment[1][2]. |
| 細胞實驗 | In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2[1]. |
| 別名 | Hemin chloride, 氯化血紅素 |
| 分子量 | 651.94 |
| 分子式 | C34H32ClFeN4O4 |
| CAS No. | 16009-13-5 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 6.5 mg/mL (10 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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