WITHAFERIN A
作者：齊岳
發(fā)布時(shí)間：2023-09-07
09:28:13
點(diǎn)擊數(shù)：
產(chǎn)品名稱：WITHAFERIN A
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 茄科 > 酸漿屬 |
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 類固醇 |
| 產(chǎn)品描述 | WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer. |
| 體外活性 | WITHAFERIN A,potently inhibits NFkappaB activation by preventing the tumor necrosis factor-induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism. |
| 體內(nèi)活性 | WITHAFERIN A Displays Anti-inflammatory Properties in Vivo—Because NFκB is a critical player in the inflammatory signaling pathway and because WITHAFERIN A inhibits NFκB activation. |
| 細(xì)胞實(shí)驗(yàn) | L929sA cells were co-treated with WITHAFERIN A and DTT for 1 h, and then TNF-induced NFκB activation was examined. |
| 動物實(shí)驗(yàn) | Mice are injected subcutaneously with zymosan in the footpad, and swelling is determined at several time points after the injection. Pretreatment with WITHAFERIN A(intraperitoneal) was performed to evaluate anti-inflammatory effects, whereas DEX (intraperitoneal) was chosen as a positive control. the mean of the differences between the zymosan-treated and untreated footpad for all the three groups. Both DEX. |
| 別名 | 醉茄素 A, 醉茄素A |
| 分子量 | 470.6 |
| 分子式 | C28H38O6 |
| CAS No. | 5119-48-2 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 27.5 mg/mL (58.44 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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