ML385
作者：齊岳
發(fā)布時間：2023-09-07
09:28:12
點擊數(shù)：
產(chǎn)品名稱：ML385
產(chǎn)品描述：
| 產(chǎn)品描述 | ML385 is a new-type and selective NRF2 inhibitor. |
| 靶點活性 | Nrf2:1.9 μM |
| 體外活性 | ML385 reduce the NRF2 transcriptional activity in a dose-dependent manner with the maximum inhibitory concentration is 5 μM. ML385 interacts with NRF2 and affects the DNA binding activity of the NRF2-MAFG protein complex（IC50=1.9 μM）. |
| 體內(nèi)活性 | ML385 in combination with carboplatin leads to a significant reduction in tumor cell proliferation, demonstrated by fewer Ki-67 positive cells. Tumor samples treated with ML385 show a significant reduction in NRF2 protein level and its downstream target genes. |
| 細胞實驗 | cells are treated with ML385 for 36 h. An equal amount of CellTiter-Blue reagent is added to the wells and the fluorescence is measured after 30 min. The CellTiter-Blue reagent is discarded and the Caspase-Glo (100 μL) reagent is added to the cells and incubated at 37°C for an additional 60-90 min. The resulting luminescence is recorded and the caspase activity is normalized to cell number |
| 動物實驗 | Mice tumor xenografts are administered intraperitoneally ML385 (30 mg/kg). |
| 分子量 | 511.6 |
| 分子式 | C29H25N3O4S |
| CAS No. | 846557-71-9 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 30 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齊岳生物科技有限公司是集化學(xué)科研和定制與一體的高科技化學(xué)公司。業(yè)務(wù)范圍包括化學(xué)試劑和產(chǎn)品的研發(fā)、生產(chǎn)、銷售等。涉及產(chǎn)品為通用試劑的分銷、非通用試劑的定制與研發(fā)，涵蓋生物科技、化學(xué)品、中間體和化工材料等領(lǐng)域。
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