5-O-Caffeoylshikimic acid
作者：齊岳
發(fā)布時間：2023-09-07
09:22:17
點擊數(shù)：
產(chǎn)品名稱：5-O-Caffeoylshikimic acid
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 八角科 > 八角屬 |
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 苯丙烷 |
| 產(chǎn)品描述 | 5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB. |
| 體外活性 | Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. RESULTS: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice[1] |
| 分子量 | 336.29 |
| 分子式 | C16H16O8 |
| CAS No. | 73263-62-4 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 50 mg/mL (148.68 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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