25S-Inokosterone
作者：齊岳
發(fā)布時(shí)間：2023-09-06
09:06:46
點(diǎn)擊數(shù)：
產(chǎn)品名稱：25S-Inokosterone
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 莧科 > 牛膝屬 |
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 其他 |
| 產(chǎn)品描述 | 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics. |
| 體外活性 | Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-Inokosterone (2), and 25R-inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α± plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (8095% at 200 μg/mL) against TNF-α± expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. |
| 分子量 | 480.642 |
| 分子式 | C27H44O7 |
| CAS No. | 19595-18-7 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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